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Notably, in SURMOUNT-1, lean mass loss as a proportion of total mass lost was similar (~25%) across the treatment and placebo groups 62 , and in the treatment group, physical function scores were improved relative to baseline and by comparison to the placebo group at the end of the study 62, 63

Figure 1 Wnt signaling is known to regulate a wide range of developmental processes such as body axis and segment polarity, mesoderm and endoderm differentiation, hair follicle and nephron development, and epithelial-mesenchymal transition (Logan and Nusse, 2004)